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KMID : 0380619890210030435
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Korean Journal of Food Science and Technology
1989 Volume.21 No. 3 p.435 ~ p.440
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Mutagenicities of Carbonyl Compounds Derived from Maillard Reaction and their Desmutagenicity Mechanisms
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김인수/Kim, In Soo
박영호/윤형식/김선봉/변한석/도정룡/염동민/Park, Yeung Ho/Yoon, Hyeung Sik/Kim, Seon Bong/Byun, Han Seok/Do, Jeong Ryong/Yeom, Dong Min
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Abstract
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The present study was attempted to investigate the mutagenicities of carbonyl compounds(methyl glyoxal, glyoxal, diacetyl, dihydroxyacetone, glycolaldehyde, glyceraldehyde and furfural) derived from Maillard reaction toward Salmonella typhimurium TA 100 (base-substitution mutant) without metabolic activation. And for further investigation of mutagenicity mechanism including desmutagenicity, active oxygen scavengers (cysteine, a-tocopherol, tris (hydroxymethyl) aminomethane, catalase, ascorbic acid) and reducing agents (glutathione, sodium bisulfite) were also used. Among carbonyl compounds tested, methyl glyoxal, glyoxal, dihydroxyacetone, glycolaldehyde and glyceraldehyde exhibited mutagenicities, and methyl glyoxal showed the strongest mutagenic activity. On the other hand, the mutagenicities of carbonyl compounds were significantly suppressed by cysteine, tris (hydroxymethyD aminomethane, glutathione and sodium bisulfite. Also, these active oxygen scavengers and reducing agents alone did not show mutagenicity in the present study.
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KEYWORD
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